Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury

Neuroprotection with erythropoietin administration following controlled cortical impact injury in rats.

This study was designed to determine the effect of erythropoietin (Epo) on cerebral blood flow (CBF), nitric oxide (NO) concentration, and neurological outcome after traumatic brain injury. In one experiment, the hemodynamic effects of Epo were determined after controlled cortical impact injury (CCII) by measuring mean arterial pressure, intracranial pressure, CBF using laser Doppler flowmetry,...

Early diffusion changes following controlled cortical impact injury on a rat model

Figure 2. Regional ADC and FA values at 2 hour and 4 hour after TBI for hippocampus ipsilateral (hip_ips) and contralateral (hip_con) , thalamus ipsilateral (tha_ips) and contralateral (tha_con), olfactory ipsilateral (of_ips) and contralateral (of_con). Error bar shows standard error (= standard deviation/√sample size). ( * is for significance level of p < 0.05. # is for significance level of ...

Mouse Brain PSA-NCAM Levels Are Altered by Graded-Controlled Cortical Impact Injury

Traumatic brain injury (TBI) is a worldwide endemic that results in unacceptably high morbidity and mortality. Secondary injury processes following primary injury are composed of intricate interactions between assorted molecules that ultimately dictate the degree of longer-term neurological deficits. One comparatively unexplored molecule that may contribute to exacerbation of injury or enhancem...

Controlled cortical impact model for traumatic brain injury.

Every year over a million Americans suffer a traumatic brain injury (TBI). Combined with the incidence of TBIs worldwide, the physical, emotional, social, and economical effects are staggering. Therefore, further research into the effects of TBI and effective treatments is necessary. The controlled cortical impact (CCI) model induces traumatic brain injuries ranging from mild to severe. This me...

Characterization of the Neurogenic Microenvironment in the Mouse Hippocampus following Chemical-induced Neuronal Injury